When there is a choice between such drugs as Amoxiclav and Flemoklav Solyutab, it is necessary to compare them according to the mechanism of action, composition, properties. These funds represent a group of penicillin antibiotics, have a wide spectrum of action.
Characteristics of Amoxiclav
Manufacturer - Sandoz Gmbh (Germany). The drug is a two-component. This means that 2 substances are active in the composition: amoxicillin and clavulanic acid. However, only the first of the components provides an antibacterial effect. Clavulanic acid acts as a supportive agent. You can buy medicine in various forms of release:
- coated tablets, the dose of basic substances in 1 pc .: 250, 500, 875 mg of amoxicillin and 120 mg of clavulanic acid;
- powder for suspension: 120 and 250 mg of amoxicillin, 31, 25 and 62.5 mg of clavulanic acid;
- powder for solution for injection: 500 and 1000 mg of amoxicillin in 1 bottle, 100 and 200 mg of clavulanic acid;
- oral dispersed tablets: 500 and 875 mg of amoxicillin in 1 pc., 120 mg of clavulanic acid.
When there is a choice between such drugs as Amoxiclav and Flemoklav Solyutab, it is necessary to compare them according to the mechanism of action, composition, properties.
Amoxiclav is available in packages containing blisters with pills (5, 7, 15, 20 and 21 pcs.), And bottles of various sizes (from 35 to 140 ml). The main medicinal property is antibacterial. The drug is included in the group of antibiotics, contains a penicillin derivative. Amoxicillin is a semi-synthetic substance.
Clavulanic acid helps to preserve the properties of the antibiotic for a long period by suppressing the activity of beta-lactamases produced by harmful microorganisms. As a result, the ability of bacteria to inhibit the function of this antibiotic is suppressed. The level of efficacy of the drug is not reduced, it becomes possible to use in pathological conditions provoked by pathogenic particles that contain beta-lactamase.
The drug has a bactericidal effect on harmful microorganisms. As a result, during Amoxiclav therapy, their death occurs. The desired effect is achieved by deforming the bacterial cell wall. The process of peptidoglycan production is impaired. This helps to reduce the strength of the cell wall of harmful microorganisms. The drug is active in the fight against such pathogenic particles:
- aerobic bacteria (gram-positive and gram-negative);
- gram-positive anaerobic bacteria.
Thanks to clavulanic acid, it became possible to use amoxicillin in the fight against pathogenic particles that are resistant to this antibacterial substance. Due to this, the range of application of the drug is somewhat expanded.
The main components of the drug are rapidly absorbed, spread throughout the body. Both substances are characterized by high bioavailability (70%). They begin to act simultaneously - 1 hour after the first dose. Active substances accumulate in biological fluids, tissues and various organs.
If the liver is damaged, it may be necessary to adjust the treatment regimen. This reduces the dosage of the drug, because diseases of this organ contribute to slowing the excretion of the active substance from the body, which leads to a gradual increase in its concentration. The first of the components passes into breast milk.
The drug Amoxiclav has a bactericidal effect on harmful microorganisms. As a result, during Amoxiclav therapy, their death occurs.
Indications for use:
- pathological conditions caused by infection and accompanied by inflammation with localization of the lesion in the upper, lower respiratory tract, lor-organs: sinusitis, sinusitis, pharyngitis, pneumonia, etc .;
- diseases of the female and male genital organs;
- lesion of the urinary system, accompanied by inflammation: cystitis, prostatitis, etc .;
- hereditary lung diseases in children (the drug is prescribed in the acute period, with complex treatment);
- infectious diseases of the skin;
- diseases of the abdominal organs, biliary tract, bone tissue, provided that the cause is a defeat by harmful microorganisms;
- STD infections;
- preventive measures to prevent the development of complications after surgery.
Contraindications Amoksiklava few:
- hypersensitivity to any active substance of the drug;
- pathological conditions such as lymphocytic leukemia, infectious mononucleosis;
- liver disease.
If you plan to take pills, it should be noted that the drug in this form is not prescribed to children under 12 years of age, as well as in cases where the child’s body weight is less than 40 kg.
If you plan to take pills, it should be noted that the drug in this form is not prescribed to children under 12 years of age, as well as in cases where the child’s body weight is less than 40 kg. Other contraindications for taking pills: phenylketonuria, renal dysfunction. With caution appoint a means during pregnancy and feeding. During antibiotic treatment, there is a risk of side effects:
- disruption of the liver;
- damage to the mucous membranes of the digestive tract;
- emetic urges;
- change the color of tooth enamel to darker;
- allergic reaction in the form of dermatitis, eczema, urticaria;
- disruption of the blood-forming system: changes in the properties and composition of the blood;
- candidiasis with antibiotics;
- diseases of the urinary system.
If you study the drug interaction of Amoxiclav with other drugs, you need to know that the absorption of this drug slows down under the influence of antacids, glucosamine. Ascorbic acid, on the contrary, accelerates this process. Diuretics, NSAIDs, as well as drugs that affect tubular secretion, increase Amoxiclav concentration.
Caution is prescribed Amoxiclav during pregnancy and feeding.
If the patient has difficulty swallowing pills, dispersible pills are prescribed. However, the drug in this form contributes to the effectiveness of anticoagulants. In addition, this tool is not recommended to take simultaneously with antibiotics, which are characterized by a bacteriostatic action. In this case, there is a decrease in the effectiveness of Amoxiclav.
How does Flemoklav Solyubab work?
Manufacturer - Astellas (Netherlands). The drug contains active ingredients: amoxicillin, clavulanic acid. Form release - tablets dispersed in the mouth. Hence, the principle of action of this tool is the same as that of Amoxiclav.
Comparison of Amoxiclav and Flemoklava Solyutab
The preparations contain the same active ingredients. Thanks to this, Flemoklav Solyutab exhibits the same properties as Amoxiclav. The scope of these tools is the same as the mechanism of action. Both drugs can be purchased in the form of tablets dispersed in the mouth.
What is the difference?
Flemoklav Solyutab is available only in tablets that need to be absorbed in the mouth, while Amoxiclav can be found in pharmacies in the form of film-coated tablets, powder for preparing a solution for injection, suspension. Another difference is the cost.
What is cheaper?
Price Amoksiklava varies from 250 to 850 rubles. Flemoklav Solyutab can be purchased for 335-470 rubles. depending on the dose of active ingredients. Given that the drug is available in the form of tablets that are dispersed in the oral cavity, in order to determine a more affordable product, you need to find out the cost of Amoxiclav in the same form. So, you can buy it for 440 rubles. (875 and 125 mg, 14 pcs.). Flemoklav Solyutab with the same dose of active ingredients and the number of tablets costs 470 rubles. Amoxiclav is insignificant, but wins over its counterpart in price.
Which is better: Amoxiclav or Flemoklav Solyutab?
According to the degree of effectiveness of these funds are the same, because they contain the same basic substance exhibiting antibacterial activity, as well as clavulanic acid. If we compare drugs in the form of tablets dispersed in the oral cavity, they act equally effectively. When comparing Flemoklav Solutab with Amoxiclav in the form of a solution or film-coated tablets, a higher effectiveness of treatment is noted when using the last of the remedies.
Valentina, 43, Ulyanovsk
Took Amoxiclav with endometritis. Given that I have diabetes, it was not easy to find a suitable drug, because not all drugs are used for this diagnosis. No complications, recovered quickly.
Veronika, 39 years old, Vologda
The doctor prescribed Flemoklav to the child. It was said that this remedy should be combined with probiotics, so that later there is no need to eliminate the symptoms of dysbiosis. I have never done this before, and as a result, after a course of antibiotics, I had to recover for a long time. This time there was no trouble: the drug began to act immediately, on the second day the condition improved (there was bronchitis), symptoms of digestive disorders did not appear.
Doctors reviews about Amoxiclav and Flemoklav Solyub
Lapin R.V., 38 years old, Samara
The drug acts gently. Even with an overdose, it is enough to interrupt the course, perform a gastric lavage, and remove excess substance with enterosorbents. Other manipulations are not carried out. Side effects during therapy with this tool rarely develop, the price is low.
Bakieva E. B, 41 years old, dentist, Tomsk
Flemoklav Solyutab is effective in various infections. The field of action of the drug is expanded by clavulanic acid. This substance violates the integrity of the membranes of bacteria, increasing the effectiveness of the drug.