One of the most common antidiabetic drugs from the sulfonylurea group is Amaryl.
Due to the active and additional components, the drug helps to reduce the concentration of glucose and effectively reduces the severity of symptoms of diabetes.
Medicinal antidiabetic agent Amaril accepted for use for oral administration. The common international name of the drug is Amaryl. The drug is manufactured in Germany, the manufacturer - the company Aventis Pharma Deutschland GmbH.
The drug is available in different packages depending on the amount of the active substance:
- Amaryl 1 mg;
- Amaryl 2 mg;
- 3 mg Amaryl;
- Amaryl 4 mg.
Packaging sizes can vary, the number of tablets in each - from 30 to 120. The appearance of the drug also varies depending on the concentration of glimepiride and metformin. Tablets with 1 mg of the active ingredient - pink, 2 mg - green, 3 mg - yellow. Coloring Amaryl tablets 4 mg - blue. The tablet form is flat on both sides, oval. On tablets, regardless of the concentration of the active component there is an engraving: "ff" and "NMK", which can help distinguish a fake.
In addition to the standard drug, there is a combined - Amaril m. It differs from Amaril in its composition. In addition to the main component of glimepiride, the drug contains another component with hypoglycemic effect - metformin. The combined tool is available in only two dosage options:
- Glimepiride (1 milligram), metformin (250 mg).
- Glimepirid - 2 mg, metformin - 500 mg.
Amaryl M tablets look the same, even if the dosage of glimepiride is different: the shape of the tablets is round, flat, the color is white.
The main properties of the drug
The main active component of the drug - glimepiride (Latin name - Glimepiride) actively influences the release of insulin.
Due to this component, the drug has a pancreatic effect.
With the release of the hormone from beta cells, there is a significant decrease in blood sugar levels. This mechanism of action is associated with an improvement in the susceptibility of beta cells to glucose.
In addition to the main active component of the drug includes the following additional substances:
- lactose monohydrate;
- indigo carmine;
- magnesium stearate;
- microcrystalline cellulose.
In addition, the drug regulates the production of pancreatic hormone. This is due to the interaction of glimepiride and metformin with potassium channels on the membrane of the beta cells. The binding of the active component to proteins regulates the activity of the channel, namely, closure and opening.
Amaril has extrapancreatic effect - improves insulin utilization by muscles and adipose tissue. This happens as a result of blocking the potassium channels in the cell membrane and the increased flow of calcium into the cells. Extrapancreatic effect causes a decrease in insulin resistance, but also slightly affects the functioning of the heart and blood vessels.
The highest concentration of the active substance is achieved with frequent use. For example, when taking 4mg glimepiride per day, the highest concentration is achieved in 2.5 hours.
Full absorption of the drug is achieved only when taken orally. Eating a little slows down the process of absorption of the drug, but this effect is negligible. Excretion of glimepiride passes through the intestines and kidneys.
List of indications and contraindications for admission
Amaryl has the following indications for use. The main one is the treatment of type 2 diabetes. Amaril's reception is justified both for patients who do not need insulin injections, and for those who are shown insulin to improve their well-being.
In the treatment of diabetes Amaryl tablets are prescribed mainly as the main drug. But with insufficient metabolic control (especially if the patient is prescribed a dosage of the drug), Glimepiride is prescribed in combination with Metformin. This can significantly improve metabolic control. At the same time, the results are much better compared to those achieved with a separate intake of drugs.
The good effect achieved as a result of complex therapy with Glimepirida and Metformin, has led to the development of the complex drug Amaryl M. For this medicine, the prescription is given out if diabetes treatment with complex drugs is necessary, which is convenient for patients.
The sugar-reducing drug Amaril can be taken by patients in need of regular insulin injections. At the same time, metabolic control also improves, but the dosage of Glimepirid is recommended to be reduced.
As with any medication, the drug can not be considered absolutely safe. The drug Amaryl has contraindications, and their list is quite large.
First of all, it is recommended to be wary of taking the medicine at the first stage of treatment: during this period there remains the risk of a sharp decrease in the level of glucose. If the risk of hypoglycemia remains over time, it is recommended to change either the treatment regimen or the dosage of Amaril. Careful need to be necessary for certain diseases, unhealthy lifestyle, unbalanced diet.
The main contraindications to the appointment of Amaril are the following diseases (or body conditions):
- Diabetic coma or ancestor.
- Severe liver and kidney disease.
- Intolerance or hypersensitivity of the main or additional components of the drug.
- Rare hereditary diseases (lactose intolerance, lactase deficiency, etc.).
- Pregnancy. During pregnancy planning, the treatment regimen must be replaced. The patient is transferred to insulin injections, the drug is not prescribed.
- During breastfeeding, insulin therapy continues. If for any reason such a treatment regimen is not suitable, Amaryl is prescribed to the patient, but it is recommended to stop lactation.
No drug is prescribed for the treatment of type I diabetes. The absolute contraindication is the child age. Clinical data on the tolerability of drugs in children are missing.
Therefore, for the treatment of diabetes in children, safer drug analogues are usually prescribed.
Side effects of using the funds
As a result of taking Amaril, side effects may occur.
In some cases, there is the likelihood of failures in the work of various organs and body systems.
On the metabolic side, hypoglycemic reactions are observed. They usually occur very quickly, but are extremely difficult to treat.
Some pills for diabetes cause disorders of the central nervous system.
Those who take Amaril also have similar symptoms:
- deterioration of attention;
- lack of coordination;
- slow reaction;
- worsening sleep;
- confusion or loss of consciousness;
- depressed state;
- speech impairment;
- nervousness, anxiety, etc.
The effects of taking the drug as a violation of the digestive tract are common. They can manifest as pain in the stomach or abdomen, nausea, diarrhea, vomiting, increased hunger.
Due to the effects of glimepiride, a decrease in the level of glucose is possible, which can adversely affect the state of the organs of vision, due to which vision can be impaired.
The drug affects the blood formation processes, which can create the danger of such changes as:
- Thrombocytopenia (of varying severity).
Standard allergic reactions are less common:
- skin rash;
- redness of the skin;
After taking Amaril's medication, the symptoms of allergy are most often not pronounced and with proper treatment they pass quickly.
But it is extremely important to start treatment in time: the danger of anaphylactic shock remains.
Instructions for use of the drug
Effective treatment is impossible without following the instructions for use of Amaril. The basic rule of admission - the tablet in no case can not be crushed. Take Amaryl 3 tablet must be completely, squeezed with plenty of water to facilitate swallowing.
The optimal dose of Amaril is calculated individually for the patient. The main parameter, which are oriented in the appointment of the drug - the concentration of glucose in the blood. The lowest dosage possible is prescribed, which can help normalize metabolic control. In addition to the glucose level, in the instructions section, the method of use of the drug indicates that constant monitoring is required not only of the glucose level, but also of glycosylated hemoglobin.
There are situations when the patient forgot to take Amaryl tablets on time. In such cases, it is not recommended to replenish the amount of the drug, doubling the dosage. Usually the dosage remains the same, the missed pills are not replenished. It is better to talk in advance with a doctor about actions in such situations.
In the first stage of treatment, patients are prescribed Amaryl 1 mg per day. Over time, if the need arises, a gradual increase in the dose of the drug by 1 mg, up to 6 mg per day, and then up to 8 mg, is allowed. With normal disease control, the maximum dosage does not exceed 4 mg per day. A large dose of more than 6 mg per day rarely gives noticeable improvements. The amount of the drug in 8 mg is prescribed in exceptional cases.
The interval between each increase in dosage is determined by the patient's condition and the effectiveness of the amount of medication taken, but should not be less than 1-2 weeks.
It is necessary to take the drug after a meal, as hypoglycemia may occur otherwise.
The combined drug Amaryl M should be taken on the same principle. The dosage of the medication indicated by the prescription is divided into 2 doses: in the morning and in the evening, or taken in full at once. Most often, patients are recommended to take Amaril 2m + 500 mg.
The amount of Amaryl for diabetes in elderly patients is chosen with extreme caution, and the treatment is carried out with constant monitoring of the kidneys.
Additional information about the drug
When prescribing Amaril or Amaril M, the doctor must not only give instructions on the correct use of the drug, but also warn about possible side effects. Especially you need to pay attention to the risk of hypoglycemia, which can develop if the patient forgets to take food immediately after taking Amaril. To avoid hypoglycemia, it is better to have a piece of sugar or candy.
In addition to the level of sugar and glucose concentration in the urine, the patient should regularly check the work of the kidneys and liver.
A common question is whether it is possible to take alcohol during therapy with Amaril. It is worth remembering that alcohol is usually poorly tolerated during the treatment of diabetes and does not combine with most drugs. These include Amaryl. The consequences of taking both medication and alcohol can be unpredictable. In some cases, the effectiveness of the drug becomes higher, while in others it is significantly reduced. Therefore, at the time of treatment, you must either give up alcohol and alcohol-based drugs.
As for the interaction of Amaril with other drugs, everything here also depends on the type of drug. Taking certain medications improves the effectiveness of Amaril, others - reduces the effectiveness. The list of those and other drugs is quite extensive. Therefore, if necessary, take other medicines, you must inform your doctor about the diagnosis and the drug being taken. In this case, the doctor will be able to pick up a drug that will not have a significant impact on the effectiveness of Amaril.
If any side effects occur, the medication should be stopped and consult a doctor.
Only a doctor can recommend suitable Amaril analogues.
During the application of Amaryl in type 2 diabetes, I received positive feedback from many patients. This confirms the fact that with the proper selection of the dosage, the drug effectively fights hyperglycemia.
In addition to the effectiveness, many buyers called the different colors of tablets a positive quality of the drug - this helps not to confuse medications with different dosages of glimepiride.
The feedback received on Amaril confirmed not only its effectiveness, but also the side effects indicated in the Amaril instructions.
Most often, patients taking medication show signs of hypoglycemia:
- Shivering all over.
- Increased appetite.
Often as a result of hypoglycemia in diabetes mellitus there is a danger of losing consciousness. Therefore, those who take Amaryl, have to constantly carry with them sugar-containing products (for example, candy) in order to be able to quickly increase their sugar levels and improve their well-being, if necessary. However, according to doctors, the change in sugar level is not an indicator of the ineffectiveness of the drug. If these symptoms appear, it is enough to adjust the dose.
A common problem for drivers who are forced to take glucose-lowering drugs is the deterioration of the reaction while driving. A similar side effect is indicated in the instructions in the list of possible side effects. The decrease in the reaction is due to the influence of glimepiride on the nervous system.
Among older patients with diabetes, in reviews about Amaril, many noted another negative point: despite the effectiveness with which Amaryl sugar level reduces, the medicine for diabetes has a high price, since the drug may cost more than some analogues, including Russia’s production.
Price and analogues of the drug
It is possible to purchase Amaril in an ordinary city pharmacy, but there is one nuance: it is not available for sale. As with many other antidiabetic drugs, you will have to show a prescription to buy Amaryl.
Another popular question of many diabetics is how much Amaril costs. The price of the drug in this case will depend on the number of tablets in the package and the dosage of the drug. For example, the packaging of the drug on 30 tablets costs, depending on the dose, from 200 to 850 rubles. At the same time, Amaril 1 mg costs on average 230-280 rubles, the packaging of Amaril tablets 2 mg - 450-560 rubles, 3 mg - for 630-830 rubles. The most expensive tablets Amaryl 4 mg 90 pcs. - they cost an average of 870-1080 rubles.
The drug Amaryl M can be bought for 570-600 rubles. It is important to bear in mind that for such a price you can buy Amaril tablets 2 mg + 500 mg. It is very difficult to purchase a lower dosage (1 mg + 250), since it is less often prescribed by doctors, respectively, less often goes on sale.
There are a lot of drugs of similar effect. The most common analogues are:
- Glucofage 850.
For example, Amaryl is often substituted with Gliclazide (GLN - Gliclazide). It also belongs to the sulfonylurea group.The composition of the drug is only the active substance - gliclazide and additional components. The drug affects beta cells, improving insulin production. In addition, the drug helps with edema, as it improves blood microcirculation, inhibits adhesion of platelets, thereby reducing the risk of thrombosis and other complications.
What hypoglycemic drugs are most effective expert will tell in the video in this article.