Treatment and Prevention

How to use the drug Augmentin 500?

Augmentin 500 is a popular antibiotic with a wide spectrum of action. The drug effectively fights numerous pathogens that are hypersensitive to amoxicillin and clavulanic acid.

ATH

Code J01CR02.

Augmentin 500 is a popular antibiotic with a wide spectrum of action.

Forms of release and composition

The drug is produced in the form of tablets with a dosage of the active substance 500 mg / 125 mg. Active ingredients - amoxicillin and clavulanic acid. Additional ingredients:

  • magnesium stearate;
  • sodium starch glycolate type A;
  • silica colloidal anhydrous;
  • microcrystalline cellulose.

In addition, the drug is available in powder form for the preparation of suspensions for oral administration and solution for injection. But such forms of medicine are less popular with doctors, and they are prescribed mainly by patients who are in hospital.

Suspension for internal administration has the following dosage: 125, 200, 400 mg, and intravenous solution: 500 or 1000 mg.

pharmachologic effect

Amoxicillin is a semisynthetic antibacterial agent with a broad spectrum of action. It is active against many gram-positive and gram-negative microorganisms. In this case, amoxicillin is able to collapse under the action of β-lactamase, therefore, the spectrum of activity of this drug does not apply to microorganisms that produce this enzyme.

The active ingredient amoxicillin is a semi-synthetic antibacterial agent with a broad spectrum of action.

Clavulanic acid is a β-lactamase inhibitor that is structurally related to penicillins and is capable of inactivating a wide range of β-lactamases detected in microorganisms resistant to penicillins and cephalosporins.

Clavulanic acid is effective against plasma β-lactamase, which often cause bacterial resistance. Thanks clavulanic acid can protect amoxicillin from destruction by enzymes - β-lactamases. In addition, Augmentin's antimicrobial spectrum is expanded.

Pharmacokinetics

Active ingredients leave the body with urine in the form of inactive penicillic acid in the amount of 10-25% of the dose taken.

Indications for use

The drug is prescribed to treat the following types of infections:

  • upper respiratory tract: recurrent tonsillitis, sinusitis, otitis media;
  • lower respiratory tract: exacerbation of chronic bronchitis, lobar pneumonia, bronchopneumonia;
  • urinary system: cystitis, urethritis, pyelonephritis, gynecological infections, gonorrhea;
  • skin and soft tissues: cellulite, animal bites, acute abscesses and cellulitis of the maxillofacial area;
  • infections of bones and joints: osteomyelitis.

Also, the tool has proven itself in the treatment of septic abortion, generic and intra-abdominal sepsis.

Augmentin is indicated for use with otitis media.
The exacerbation of chronic bronchitis is an indication for Augmentin's use.
Augmentin is used in the treatment of cystitis.
With the help of Augmentin, cellulite treatment is carried out.

Can it be used for diabetes?

The instructions for use indicate that patients with diabetes can take Augmentin, but only with caution. During a therapeutic course, blood glucose monitoring is required.

Contraindications

The drug in the form of tablets is prohibited to receive in the following cases:

  • allergic reaction to the components of the drug;
  • hypersensitivity to other beta-lactam antibiotics;
  • jaundice or impaired liver function;
  • children under 12 years of age or patients weighing less than 40 kg.

Use during pregnancy and lactation

The drug should not be used during childbirth, because Mass research on the effect of antibiotic on the fetus has not been conducted. The drug can be administered to women during lactation, but with the development of undesirable effects, treatment will have to be stopped.

The drug should not be used during childbirth, because Mass research on the effect of antibiotic on the fetus has not been conducted.

How to take Augmentin 500?

Before taking the drug, it is important to determine the sensitivity of microflora to the drug, which led to the development of the patient's disease. The dosage is set individually and depends on the severity of the pathological process, the localization of the infection and the sensitivity of the pathogen.

Adults and children from 12 years old with a body weight of more than 40 kg are prescribed 1 tablet 3 times a day, provided that the infectious process is mild or moderate. In severe form of pathology, other forms of Augmentin are shown.

The minimum course of therapy is 5 days. After 2 weeks of treatment, the physician must assess the clinical situation in order to decide on the continuation of the course of antibacterial treatment.

Patients younger than 12 years old are shown the drug in the form of syrup. Single dose depends on age:

  • 7-12 years old - 10 (0.156 g / 5 ml) or 5 ml (0.312 g / 5 ml);
  • 2-7 years - 5 ml (0.156 g / 5 ml).

Side effects

Adverse events often occur with increasing dosage of the drug.

Gastrointestinal tract

Nausea, vomiting, diarrhea.

Blood and lymphatic system

Reversible leukopenia.

central nervous system

Dizziness, migraine.

Nausea and vomiting may occur while taking the drug.
In some cases Augmentin causes diarrhea.
Augmentin can cause migraines and dizziness.
Adverse symptoms often occur in the case of Augmentin overdose.

On the part of the urinary system

Interstitial nephritis, hematuria and crystalluria.

The immune system

Angioedema, anaphylaxis, serum syndrome and vasculitis.

Liver and biliary tract

A moderate increase in the concentration of liver enzymes ALT / AST.

special instructions

Before starting therapy, the physician should collect a detailed history that includes previous reactions to penicillins, cephalosporins, or other beta-lactam antimicrobials.

Before starting treatment with Augmentin, the doctor must collect a detailed history.

Compatibility with alcohol

It is undesirable to use Augmentin together with alcoholic drinks, since this is fraught with increased load on the liver and kidneys.

Influence on ability to operate mechanisms

An antibacterial agent may cause dizziness, therefore, during the course of therapy from driving a car and working with complex mechanisms, it will have to be abandoned.

Use in old age

For people in old age, dosage reduction is not required. If patients have impaired renal function, the norm of the drug is adjusted by a doctor.

Dosage for children

Children up to 12 years old have developed a suspension. Her dosage is determined by the patient's age.

Patients with impaired renal function

Dosage adjustment is based on the maximum recommended drug rate and the value of creatinine clearance.

Patients with impaired liver function

The treatment is performed with caution, it is necessary to regularly monitor the functioning of the liver.

With an overdose of Augmentin, abdominal pain may occur.
In excess, Augmentin may cause flatulence.
Overdose Augmentin manifested through pallor of the skin.
Slow pulse - a sign of overdose.
If therapy is accompanied by similar symptoms, you need to stop the course and consult a doctor.

Overdose

The symptoms of overdose are as follows:

  • abdominal pain, flatulence, diarrhea, nausea, vomiting;
  • pallor of the skin, slow pulse and lethargy;
  • convulsions;
  • signs of kidney damage.

With the development of the indicated symptoms, the patient should stop taking the antibiotic, consult a doctor for the appointment of symptomatic therapy. In the hospital, the patient will be washed in the stomach, given a sorbent and cleaned the blood by hemodialysis.

Interaction with other drugs

Do not use Augmentin in combination with Probenecid. If you combine the antibiotic with allopurinol, then there is a risk of developing allergies. The combination of antimicrobial drug with Methotrexate increases the toxic effect of the latter.

Analogs Augmentina 500

Augmentin has a similar composition with Amoxiclav, and the mechanism of action is identical to Supraksu.

Pharmacy vacation terms

On prescription.

Price

The average cost of the drug is 250-300 rubles.

Augmentin storage conditions 500

Keep the drug should be at a temperature not higher than + 25 ° C, in a dry and dark place inaccessible to children.

Doctor's reviews of Augmentin: indications, use, side effects, analogues
Quickly about medications. Amoxicillin
Quickly about medications. Amoxicillin and clavulanic acid

Shelf life of the drug

An antibiotic can be used for 3 years from the date of production.

Reviews for Augmentin 500

Doctors

Nikolay, 43, Sevastopol: “I often use this antimicrobial drug in my medical practice. I prescribe it for the treatment of diseases of the upper respiratory tract. Of the advantages it is necessary to note the high efficacy and the absence of drug dependence, but the medication has disadvantages: high price and increased risk development of adverse reactions. "

Svetlana, 32, Magnitogorsk: “I prescribe this remedy for the treatment of respiratory infectious pathologies in children. I prescribe a drug in the form of a syrup that has a pleasant taste and aroma. My little patients take it with pleasure. If you prescribe an antibiotic in the correct dosage and follow for the patient's condition, the risk of adverse symptoms is minimized, and positive results are observed for 2-3 days of admission. "

Keep the drug should be at a temperature not higher than + 25 ° C, in a dry and dark place inaccessible to children.

Of patients

Sergei, 35, Moscow: "When diagnosing a smear from the urethra, the gonorrhea pathogen was detected. Augmentin tablets were prescribed as part of the combined therapy. The course lasted 7 days, after which all the symptoms of the disease were eliminated."

Olga, 24, Nizhny Novgorod: "I had a difficult birth after which I developed sepsis. Doctors prescribed an intravenous antibiotic solution. I was injected 2 times a day for 5 days. After completing the course, I felt good for myself."

Vladimir, 45, Yekaterinburg: “A couple of years ago, pyelonephritis was diagnosed. Augmentin was used to treat pathology because he was worried about high body temperature and soreness in the lumbar region. After 2 days of taking the pills, he felt relief. In addition, he combined the antimicrobial drug active supplements, but there were no adverse symptoms. "

Watch the video: How To Properly Take An Antibiotic Suspension (April 2020).