Treatment and Prevention

Glucophage in gynecology: the nuances of treatment with polycystic ovarian drug

Glyukofazh with polycystic ovary is part of a comprehensive treatment of the disease, which aims to eliminate cystic formations, the resumption of the ovulatory function of the glandular organs and the ability of a woman to reproduce.

The tool is assigned to the fair sex, who suffer from diabetes and can not get pregnant.

The fact is that often it is insulin deficiency and hyperglycemia that lead to the development of multiple cysts on the ovaries. Glyukofazh 500 in gynecology helps to normalize the process of maturation of the egg and resume menstruation. To achieve the positive effects of therapy, doctors prescribe a drug to women from day 16 to day 26 of the cycle.

What is Glucophage?

Glucophage is an antidiabetic monotherapy, the main component of which is the biguanide metformin. It reduces the amount of glucose in the blood plasma before and after meals, without affecting the insulin production by the pancreas.

Drug Glucophage

The active substance acts in the following ways:

  • inhibits the breakdown of glycogen in the liver, which reduces blood glucose levels;
  • increases insulin sensitivity, helping to improve glucose uptake from the periphery;
  • suspends the absorption of simple carbohydrates in the intestinal tract.

In addition, Glucophage stimulates the synthesis of glycogen from glucose and has a positive effect on the metabolism of lipid compounds.

Indications for use of the drug:

  • diabetes mellitus type 2 in adults (especially associated with obesity) with relative or absolute failure of diet therapy;
  • hyperglycemia, which is a risk factor for diabetes;
  • impaired glucose tolerance to insulin.

Features of use of the drug in polycystic ovary syndrome

Polycystic ovary syndrome or PCOS is the most common reproductive disease in women aged 16 to 45 years.

Pathology is among the endocrine disorders based on hyperandrogenism of ovarian origin and anovulatory cycle. These disorders cause complex variants of menstrual dysfunction, hirsutism and are the main cause of secondary infertility.

Polycystic Ovary Syndrome

Scientists were able to notice the pattern that women suffering from PCOS are overweight in 70% of clinical cases and almost every fourth of them have impaired glucose tolerance or diabetes.

This prompted the doctors to the next thought. Hyperandrogenism and hyperglycemia are two interrelated processes. Therefore, the appointment of Glucophage with PCOS, reducing insulin resistance, makes it possible to normalize the monthly cycle, eliminate excess androgens, and stimulate ovulation, which can result in pregnancy.According to numerous studies in this area, it was found:

  • after six months of taking the drug in women, the rate of glucose utilization in the blood increases significantly;
  • after six months of therapy, it is possible to establish a regular menstrual cycle with ovulation in approximately 70% of patients;
  • Every eighth woman with PCOS becomes pregnant by the end of the first course of such treatment.
The dosage of Glyukofaza with polycystic ovary is 1000-1500 mg per day. Although this indicator is relative and depends on the degree of hyperglycemia, the individual characteristics of the organism, the level of ovarian androgens, the presence of obesity.


Unfortunately, Glyukofaz in case of polycystic ovary can take far from all patients, since the drug has a number of contraindications to use, among which are:

  • ketoacidosis triggered by diabetes mellitus;
  • severe precomatosis complications of diabetes;
  • kidney and liver failure;
  • acute alcohol poisoning and alcoholism;
  • individual intolerance to the components of the drug;
  • acute pathological conditions occurring on the background of serious impairment of renal function (chic, dehydration);
  • diseases causing acute tissue hypoxia, namely: respiratory failure, acute myocardial infarction, toxemic shock.
Glyukofazhem therapy should be canceled in the event of pregnancy. During the period of breastfeeding, the drug should be taken with great caution, as it is excreted in breast milk.

Adverse reactions to the drug

If you believe reviews about the treatment of Gluconage PCOS, then at the initial stages of taking the drug can cause a lot of adverse reactions that do not need to cancel the funds and go away on their own for several days.

Among the undesirable effects of therapy, patients emit nausea, occasional vomiting, the appearance of pain in the abdomen, upset stools, loss of appetite.

Fortunately, such reactions do not occur often and are not dangerous for the normal functioning of the body. The most common side effects of the digestive tract, which are manifested by dyspepsia, pain in different parts of the abdomen, and appetite disorders.

All these symptoms go away after a few days from the start of therapy. You can avoid them if you use the drug in several doses (recommended 2-3 times a day) after or during meals. A number of patients also have impaired nervous system, namely the lack of taste.

Gluconage in case of polycystic ovary can cause the appearance of metabolic disorders in the form of lactic acidosis.

Also, with long-term medication from the group of metformin, a decrease in the absorption of cyanocobalamin (vitamin B12) is observed, which subsequently leads to the development of megaloblastic anemia.

It is extremely rare for women to be diagnosed with negative reactions from the liver and biliary ducts, as well as the skin. Violations of the functioning of the hepatobiliary system manifest latent hepatitis, which disappear after stopping the medication. Erythema, itchy rashes and redness may appear on the skin, but this is more a rarity than a pattern.

Interaction with other drugs and alcohol

Glucophage in PCOS should be used with caution along with drugs that have an increase in blood glucose levels, such as glucocorticosteroids and sympathomimetics.

Do not use the drug in combination with loop diuretics.

Such actions increase the risk of lactic acidosis as a result of reduced kidney function.

Before conducting x-ray studies with intravenous iodine-containing contrast, it is necessary to discontinue Glyukofazh two days before the procedure. Neglect of this recommendation in most cases ends with the development of renal failure.

When treating the drug should avoid alcohol because of the increased risk of symptoms of lactic acidosis.


In most clinical options for Glucophage with polycystic ovaries, the reviews are positive.

According to them, the drug is well tolerated by the body, is not addictive, and over time allows to achieve the desired result using exclusively conservative methods of therapy.

The only time half the patients who had tried the drug had side effects at the beginning of the treatment, but they went quickly without having to cancel the course of taking the medication.

Related videos

Diet - an important point in the complex therapy of polycystic ovaries:

Numerous positive reviews of Glyukofazh long with PCOS suggest that this drug is really effective in relation to polycystic damage to the ovaries and the associated hyperandrogenism of the same genesis. Long-term use of the drug allows women not only to get rid of the problem of cyst formation, but also to resume the normal menstrual cycle, stimulate ovulation and, as a result, become pregnant, even with such a concomitant diagnosis as diabetes.

Watch the video: Womens Health. On Call with the Prairie Doc. Oct 1, 2015 (April 2020).