Thrombomag is a drug of the NSAID group, it has an antiplatelet effect. Thanks to him, the risk of developing complications caused by the formation of blood clots is reduced. Additionally, the drug exhibits other properties, in particular contributes to the elimination of inflammation.
International non-proprietary name
Acetylsalicylic acid + Magnesium hydroxide
Thrombomag is a drug of the NSAID group, it has an antiplatelet effect.
Forms of release and composition
The drug can be purchased only in the form of tablets. It represents a group of two-component tools. Compounds exhibiting activity are characterized by different properties. As active ingredients are:
- acetylsalicylic acid;
- magnesium hydroxide.
Tablets contain different amounts of these components. For example, the dose of ASA is 0.75 and 0.15 g. Magnesium chloride is contained in 1 tablet in an amount of 15.2 and 30.39 mg. Tablets are coated, but unlike analogs, grinding them before taking is allowed. Additionally, the composition of Trombomag includes components that do not show antiaggregatory and anti-inflammatory activity:
- corn starch;
- potato starch;
- microcrystalline cellulose;
- lemon acid;
- magnesium stearate.
The drug is proposed in blister packs (3 and 10 pcs.), Each of which contains 10 tablets.
The drug can be purchased only in the form of tablets.
The main objective of the drug is the inhibition of the production of thromboxane A2. This result is achieved by inhibiting the synthesis of COX-1 isoenzymes. However, there is a decrease in the intensity of the process of renal prostaglandins. Due to this, the negative manifestations of inflammation gradually disappear or their severity decreases significantly.
ASK spreads throughout the body, providing not only antithrombotic, anti-inflammatory effects, but also providing antipyretic effect. The latter property is due to the growing influence on the hypothalamus and the thermoregulation center in particular. After taking the drug, acetylsalicylic acid is metabolized, resulting in salicylates being released. These substances contribute to the reduction of the algogenic action of bradykinin, due to which there is a decrease in the severity of pain.
Due to the large number of properties that characterize the ASC, the substance is injected into the composition of many drugs. Its antiplatelet effect is due to the ability not only to suppress the synthesis of platelets, but also to reduce the rate of their binding to each other. ASC affects the erythrocyte membrane, while their tension decreases. As a result, the process of passage of red blood cells through the capillaries is facilitated, due to which normalization of blood properties is noted, and its fluidity decreases.
This effect of the drug contributes to increased bleeding. Another property of ASA aggregants is the elimination of blood clots that have appeared. All effects provided by this substance are interrelated. So, antiaggregatory property is provided by the release of prostaglandins, but with a different type of activity. This reduces the level of ionized calcium, which helps to reduce the aggregation ability of platelets.
The property of the aggregate ASA is the elimination of blood clots.
The disadvantage of the drug is the suppression of the synthesis of antithrombotic prostaglandins. This effect is provided in the case when the drug is taken in a large dose. The result is the opposite of the desired effect. For this reason, you should follow the manufacturer’s recommended daily dose (no more than 325 mg).
The other active ingredient in the composition exhibits antacid and laxative properties. Thanks to him, the risk of complications during therapy is reduced, since this substance softens the aggressive effects of ASA on the mucous membranes of the gastrointestinal tract. After taking the drug magnesium hydrochloride interacts with gastric juice, which leads to the formation of magnesium chloride.
When this substance reaches the intestines, its laxative effect is manifested. This is due to the weak ability to dissolve in such an environment. Magnesium chloride stimulates organ peristalsis. Another property is the ability to bind with bile acids. This substance is consumed by the body gradually, which contributes to its longer action.
After taking the drug magnesium hydrochloride interacts with gastric juice, which leads to the formation of magnesium chloride.
It is recommended to take the drug separately from food, because the absorption of active substances may be slowed down, which will affect the rate of their release. The components of the drug are absorbed instantly, and to the full. The process of transformation of acetylsalicylic acid is multistage. Salicylic acid is first released, which is subsequently metabolized with the advent of a number of compounds: phenyl salicylate, salicylate glucuronide, salicyuric acid.
The peak of the effectiveness of the drug occurs within 10-20 minutes after taking the pill. Extensive distribution in the body due to the high binding to blood proteins. However, this process depends on the dosage of ASA: the greater the amount of the drug taken, the worse the molecules of the substance are bound to plasma proteins.
The active components are removed from the blood quickly - within 20 minutes, the metabolites are delayed for a longer period. From the body ASA completely goes out in 1-3 days. The kidneys are responsible for the removal of the main components. The second active ingredient (magnesium hydrochloride) does not affect the bioavailability of acetylsalicylic acid.
It is recommended to take the drug separately from food.
Indications for use
This remedy is prescribed for such pathological conditions:
- primary prevention of various cardiovascular diseases: embolism and thrombosis of veins and arteries, heart failure, if there are risk factors: diabetes, hypertension, bad habits, such as smoking or alcohol abuse;
- angina of unstable nature;
- secondary prevention of myocardial infarction;
- preventing the development of complications after surgery, the risk of this increases after coronary artery bypass surgery, coronary angioplasty.
Will it help with elevated pressure?
The considered drug helps to reduce blood pressure, but to a greater extent, this effect appears after taking the pill before bedtime. It should be borne in mind that under the influence of Trombomag, the pressure may drop to a critical one. For this reason, it should not be used while taking antihypertensive drugs.
The drug has many limitations to the appointment:
- deterioration of the respiratory system during therapy with acetylsalicylic acid;
- negative reaction of an individual nature to the reception of ASC and other components in the composition;
- set of pathologies: bronchial asthma, nasal congestion, hypersensitivity to acetylsalicylic acid, in this case the risk of respiratory failure increases;
- bleeding in the digestive tract;
- cerebral hemorrhage;
- the development of erosion in the structure of the walls of the digestive tract;
- high risk of bleeding (on the background of thrombocytopenia, vitamin K deficiency, etc.);
- deficiency of glucose-6-phosphate dehydrogenase.
There are a large number of relative contraindications for which the use of medication is permissible, but caution is required:
- previously diagnosed gastric and duodenal ulcer;
- a milder form of liver and kidney function failure;
- bronchial asthma;
- pathology of the respiratory system;
- preoperative period;
- propensity for allergies.
How to take trombomeg?
In most cases, a dose of no more than 1-2 tablets per day is prescribed. The drug is taken once. The treatment regimen may vary. For example, in order to prevent pathologies of the cardiovascular system, first appoint 150 mg per day, then this amount is reduced by 2 times. In other cases, it is considered sufficient to take 1 tablet with any dosage of ASA (75 or 150 mg), which depends on the severity of the disease.
With a mild form of kidney and liver failure, the drug should be taken with caution.
The drug is approved for use, the dose adjustment is not performed, but the patient’s condition should be monitored.
Side Effects of Trombomeg
Negative reactions in the treatment of this tool are less common than in the case of acetylsalicylic acid, because the number of active ingredients is small, while the effect of tablets is further alleviated. Side effects that occur more often:
- nausea and vomiting;
Much less often the occurrence of such signs:
- general weakness;
- hearing impairment accompanied by persistent tinnitus;
- cerebral hemorrhage;
- violation of the blood system, which is manifested by anemia, thrombocytopenia, etc .;
- exacerbation of ulcerative lesions of the digestive tract, which in most cases is preceded by pain in the abdomen;
- various manifestations of allergies: swelling of the respiratory tract, itching, rash, hyperemia, rhinitis;
- impaired renal function.
Influence on ability to operate mechanisms
Driving a car is not a contraindication. However, if we consider that severe complications may develop during therapy, caution should be exercised.
When prescribing the considered agent before the operation, it must be remembered that the anti-aggregation property of the drug can manifest itself within 3 days from the moment of taking the last pill.
During therapy of patients with diagnosed disorders of the kidneys, it is necessary to constantly monitor the main indicators of the state of this organ.
At the initial and final stages of treatment should be evaluated blood composition.
Use in old age
Patients in this group increase the risk of bleeding if minimal doses of Trobomag are taken. To avoid the appearance of complications, indicators of the composition of the blood and liver are constantly monitored.
In elderly patients, the risk of bleeding increases, if minimal doses of Trobomag are taken.
Appointment to children
Use during pregnancy and lactation
The drug is not prescribed during gestation, restrictions apply only to I and III trimesters. Such contraindications are due to the risk of developing pathologies. The probability of premature closure of the arterial duct in the fetus. Heart disease may develop in a child. In the II trimester it is allowed to use the drug in an amount not exceeding 150 mg per day.
During the period of breastfeeding, this remedy is also not prescribed.
Use in violation of kidney function
Caution should be exercised, since magnesium hydrochloride can penetrate into the blood plasma. This increases the toxic effect of the substance. This process is manifested by CNS depression.
In severe renal failure, the drug is not used. In this case, you should focus on the rate of creatinine clearance (less than 30 ml per minute).
Severe liver damage is a contraindication to the drug.
Use in violation of the liver
Severe damage to this organ is a contraindication to the drug.
The effect of a number of side effects described above is enhanced. If large doses are taken, there are signs of a severe form of the pathological condition. Symptoms:
- lung hyperventilation;
- severe damage to the cardiovascular and respiratory systems.
In this therapy involves the need for gastric lavage. The patient is recommended to take the sorbent in large quantities, hemodialysis is additionally prescribed, alkaline diuresis. Measures are being taken to restore water and electrolyte balance. In case of overdose, the patient is hospitalized.
In case of overdose, therapy involves gastric lavage.
Interaction with other drugs
The effect of Methotrexate and Valproic Acid is enhanced.
Mark a number of drugs and substances, while taking which develop negative reactions:
- narcotic analgesics;
- hypoglycemic drugs;
- antiplatelet, anticoagulant and thrombolytic agents;
The level of effectiveness of ASA is reduced under the influence of a number of drugs and substances: GCS for systemic use, Ibuprofen, other antacids, which include magnesium or aluminum hydroxide.
The effect of Methotrexate is enhanced when it is co-administered with Trombomeg.
Compatibility with alcohol
Caution should be exercised in the treatment of thrombomeg, while consuming alcoholic beverages.
Substitutes that are permissible to use instead of the drug under consideration:
- Clopidogrel Plus.
Pharmacy vacation terms
The drug is a group of medicines for OTC.
Can I buy without a prescription?
There is such an opportunity.
The cost varies from 100 to 200 rubles.
Drug storage conditions
The recommended ambient temperature is no more than + 25 ° C.
It is permissible to apply the tool within 2 years from the date of issue.
Veronica, 33 years old, St. Petersburg.
A good drug. She took after surgery. Side effects, except for skin reactions at the initial stage, were not. Thanks to Trombomagu, there were no complications, which is important, since my blood is quite thick.
Elena, 42 years old, Alupka.
With hypertension, it is necessary to control the dose of the drug. If you take it uncontrollably, blood pressure can drop to a critical limit.I had a case: I forgot to take the drug in time, then I remembered and immediately drank it, but soon the next dose should come up. I did not take this into account and duplicated the reception. As a result, barely pumped out, so much pressure dropped.