Milgamma is a neurotropic drug of combined vitamin composition. The vitamins contained in the complex are indispensable for recovery measures in case of pathologies associated with inflammatory etiologies, hematopoietic disorders, and painful manifestations. Means from the manufacturer Solyupharm Pharmatshoytis Ertsoygnissse (Germany) comes to the domestic shelves in 2 forms - solid and mortar.
How does the drug work?
The main composition of the drug is vitamin elements, each of which plays an individual function:
- Thiamine (Vitamin B1).
- Pyridoxine (vitamin B6).
- Cyanocobalamin (vitamin B12, is included only in the injection of the composition).
Milgamma is a neurotropic drug of combined vitamin composition.
Thiamine is a direct participant in the metabolic reactions of carbohydrates (with its transformation into the active form of cocarboxylase). With a lack of this coenzyme, pyruvic acid accumulates in the blood, which causes a violation of the acid-base balance (acidosis). In Milgamma tablet form, thiamine is replaced by its fat-soluble analogue, benfotiamine, which performs the same functions as the water-soluble component.
Thiamine and benfotiamine specifically affect pain points, effectively relieve pain of different etiologies (joints, muscles, teeth). Once in the blood, B1 is non-uniformly distributed in its elements (75% is retained in red blood cells, 15% and 10% in leukocytes and plasma, respectively), easily overcomes any tissue (including the placenta) and is completely eliminated by the kidneys. Regular doses of this vitamin are necessary for the body, since there is no ability to accumulate it.
Pyridoxine combines the following hormones:
- dopamine (neurotransmitter cognitive activity);
- serotonin (chemical element of the brain, antidepressant);
- adrenaline (the main hormone of the adrenal glands of the brain, narrowing blood vessels, thereby mobilizing all the functions of the body);
- histamine (the strongest anti-allergen).
B6 contributes to the production of hemoglobin, is involved in the synthesis of amino acids, the metabolism of proteins, and also partially fats and carbohydrates. After penetration into the organs, the vitamin is quickly absorbed by blood cells, which organizes the transport of substances to all tissues (including the placenta), is completely absorbed in the liver, and 3-4 hours later is excreted by the kidneys.
The complex of vitamins contained in Milgamma has an improved effect on the functioning of the nervous, muscular and cardiovascular systems.
Cyanocobalamin stimulates blood formation, reduces pain associated with dysfunction of peripheral nerve nodes. This active element contributes to:
- the production of folic acid responsible for fission processes;
- the formation of choline (the building material of brain tissue);
- Creatine binding (carboxylic acid, responsible for energy exchange in muscle and brain cells).
The joint work of all vitamin elements enhances their capabilities, this has an improved effect on the work of the nervous, muscular and cardiovascular systems.
When is Milgamma prescribed?
Vitamin complex plays the role of tonic, pathogenetic and symptomatic effects and is assigned individually or as part of the treatment of many dysfunctional states of the nervous system and musculoskeletal complex.
Solid forms are available in coated tablets or enteric-coated tablets. 1 dose includes 2 main ingredients - benfotiamine (100 mg) and pyridoxine hydrochloride (100 mg) and numerous additional elements (together with the components of the outer shell):
- croscarmellose sodium;
- acacia powder;
- corn starch;
- calcium carbonate (E170);
- titanium dioxide (E171);
- macrogol 6000;
- glycerol 85%;
- polysorbate 80;
The medicine in the form of a dragee called Milgamma Compositum, it has the same basic composition and auxiliary components.
The medicine in the form of a dragee called Milgamma Compositum, it has the same basic composition and auxiliary components. The dosage of solid formulations ranges from 1 to 3 uniform units per day (as prescribed by a physician), supporting the course lasts up to 4 weeks.
Injection solution is produced in 2 ml ampoules, it includes as the main ingredients 4 active ingredients:
- thiamine hydrochloride (100 mg);
- pyridoxine hydrochloride (100 mg);
- Cyanocobalamin (1 mg):
- lidocaine hydrochloride (20 mg).
As well as auxiliary components:
- benzyl alcohol;
- sodium polyphosphate;
- potassium hexacyanoferrate;
- sodium hydroxide;
- purified water.
Injections are given on 1 ampoule per day, with a deep intramuscular injection, preferably in the morning (in the first half of the day the body is awake, and all metabolic processes occur most intensively).
Comparison of tablets and injections Milgamma
Drugs are identical in direction of action and indications for use. The main differences are to be found in the selection of the composition, individual intolerance of the added components, price and personal preferences of the patient. Since Milgamma is often indicated in complex therapy, where other drugs are present, then choosing the form, sequence and duration of administration, it is better to follow the recommendations of the attending physician.
Milgamma injection solution is produced in 2 ml ampoules.
The list of diseases for the appointment of Milgamma:
- neuritis (including retrobulbar);
- vertebral radiculopathy (sciatica);
- inflammation of the facial nerve;
- multiple sclerosis;
- alcoholic polyneuropathy;
- diabetic neuropathy;
- musculo-tonic symptoms (convulsions);
- the inability of the heart to maintain proper blood circulation (heart failure);
- children's age up to 16 years;
- breastfeeding period.
What is the difference?
If we compare the 2 existing forms of release of this vitamin means, then between them we can distinguish the following differences:
- tablets are prescribed at the primary stages of the disease or as a prophylaxis for vitamin deficiency, and injections are used to relieve acute pain spasm;
- tablet forms contain one active vitamin less (they do not contain cyanocobalamin), and thiamine is replaced by a synthetic analogue benfotiamine;
- The solutions, in addition to B1, B6 and B12, include another active ingredient - lidocaine, which acts as a local anesthetic that blocks peripheral nerve endings;
- solid forms can be consumed during the whole period of treatment (from the first day to the last), the solution form is prescribed for no more than 10 days (usually 3-5 days, until the pain disappears), later they are transferred to treatment with solid forms (the end of the course is recommended );
- pills drink 1-3 p. per day (depending on the severity of the condition), injections make only 1 p. per day.
What is cheaper?
The average price of different forms of the drug:
- tab. №30 - 656 rub .;
- tab. №60 - 990 rubles;
- injection solution number 5 (2 ml) - 270 rubles;
- injection solution number 10 (2 ml) - 450 rubles;
- injection solution number 25 (2 ml) - 1055 rubles.
Which is better, pills or injections Milgamma?
It is impossible to say unequivocally which form is more effective for patients, tablets or Milgamma injections. Solid forms often carry out preventive procedures and supportive therapy, and injections of the drug are used in the systemic treatment of the detected diseases, as well as in the composition of a selected drug complex.
Milgamma injections in conjunction with the use of alcohol is strictly prohibited.
Classic assignment scheme:
- in the form of injections (2 ml ampoules) - once a day in a course of 5 days;
- tablets - 1 pc. Once a day for 1 week;
- tablets - 1 pc. every other day course 14 days.
To choose the right form for complex treatment, one needs to know the interaction of different drugs:
- Milgamma injections are not shown with sulphate solutions, since thiamine disintegrates in this case, which means it is better to resort to tablets;
- natural B1 loses its properties in combination with oxidizing agents, phenobarbital, dextrose, glucose, iodides, acetates, riboflavin, tannin acid, carbonates (therefore it is better to use tablets with synthesized thiamine);
- B6 lowers the percentage of effective treatment while taking it together with drugs prescribed for Parkinson's disease (but the drugs can be timed);
- Vitamin B12 is useless in conjunction with products containing some heavy metal salts, so injectable forms, where cyanocobalamin is, are not required.
Milgamma injections in conjunction with the use of alcohol is strictly prohibited. Even starting a course of therapy, it is necessary to eliminate any traces of alcohol-containing substances from the body. Vitamins along with ethanol is not peculiar to digest. And lidocaine contained in the solution, contacting with alcohol, can cause severe side effects, including loss of orientation, fainting, pain in the limbs.
Margarita, 43, Moscow
Good drug. But I think that the pills have a weak effect, I prefer only injections (even for the purpose of prevention). The pain is tolerable. 3 injections is enough.
Nina, 57, Tula
The doctor said that Milgamma is indicated only for those who have low sugar. In my case, the indicators jumped to 12 and did not give in to control. We replaced the drug with Neuromultivitis, and everything returned to normal. So be careful who has diabetes, and do not engage in an independent appointment.
Pavel, 39 years old, Kaluga
But how to take these vitamins with alcoholic polyneuropathy? In contraindications it means that even with residual alcohol in the blood is impossible. And what about such dangerous side effects? It is better then to start with small doses of tablets, especially since the injections are painful anyway, even lidocaine does not save.
Milgamma vitamin complex plays the role of tonic, pathogenetic and symptomatic effects.
Doctors reviews about the pills and injections Milgamma
S.K. Mironov, manual therapist, Togliatti
Reasonable dosages of any form of the drug do not cause adverse events. But with an overdose, symptoms like rash, nausea, dizziness were noted. The most unpleasant consequences of uncontrolled doses and self-prescribing is anaphylactic shock and angioedema.
T.R. Rukavishnikov, osteopath, Murmansk
When listing the contraindications and possible consequences of an overdose, such heart disease as bradycardia would be noted, and the presence of arthrosis and functional impairment of the spine would add to the indications. You need to know that this vitamin complex is not a means for self-treatment. He, like any medication, should be taken only as prescribed by a doctor.
E.I. Serova, therapist, Izhevsk
Normal drug with rare adverse symptoms. I want to supplement the material with the fact that interactions with cycloserines, D-penicillamine, epinephrine, norepinephrine, sulfonamide reduce the effect of pyridoxine. And vitamin b1 loses its qualities with increasing pH values.