Treatment and Prevention

The drug Aspicore: instructions for use

Antiplatelet agent Aspicorus is designed for prolonged use by patients at risk of developing thromboembolic complications.

International non-proprietary name

In Latin - Aspicor

Antiplatelet agent Aspicorus is designed for prolonged use by patients at risk of developing thromboembolic complications.

ATX

B01AC06

Forms of release and composition

The drug, the active ingredient of which is acetylsalicylic acid, is available in tablet form with a special enteric coating. 1 tablet contains 100 mg of the active substance.

The form of tablets is biconvex, white. Available in blisters of 10 pieces. 3, 9 blisters and instructions for use are included in the carton. Analogs of the drug are available in the form of effervescent tablets.

pharmachologic effect

Antiplatelet properties of the drug are provided by a substance belonging to the group of salicylates. Inactivating the enzyme cyclooxygenase, acetylsalicylic acid contributes to the disruption of the synthesis of tissue enzymes of inflammation of prostaglandins. As a result of such exposure, platelets lose their ability to synthesize thromboxane. Without this enzyme, blood cells are not able to aggregate and bind to fibrin.

The effect of exposure lasts the entire period of cell activity.
It has an inhibitory effect on the formation of prostacyclin in vascular cells. This enzyme prevents the aggregation of uniform elements. Synthesis inhibition occurs only in the presence of a substance in the body. Minimal doses of drugs do not inhibit the formation of prostacyclin.

Inactivating the enzyme cyclooxygenase, acetylsalicylic acid contributes to the disruption of the synthesis of tissue enzymes of inflammation of prostaglandins. As a result of such exposure, platelets lose their ability to synthesize thromboxane.

The effectiveness of low doses is proven. This makes it possible to use the medicinal substance for prophylactic purposes. Does not affect formed blood clots, but prevents their formation.
Changing the structure of fibrin, releasing plasminogen, promotes the activation of fibrinolysis.

Pharmacokinetics

Absorbed by oral administration. Designed for absorption in the small intestine. Up to 90% is due to proteins. It takes about 3 hours to reach maximum concentration.

As a result of hydrolysis, salicylic acid anions are formed, which are freely distributed in the body. Subject to hepatic metabolism. Intensively absorbed in an acidic environment.

Absorbed by oral administration.

Through the walls of blood vessels only ionized acid molecules enter the tissues, the specific weight of which increases in an acidic medium. The use of the drug in a state of acidosis is dangerous due to the presence of risk factors for the occurrence of intoxication even at therapeutic doses.

Metabolized to form paired compounds with glycine, glucuronic acid. Excreted in the urine. The renal tubules secrete up to 60% of the active component and metabolites. The half-life depends on the dose, the acidity of the medium.

What is prescribed

The drug is available in dosage, calculated because of the data on long-term use. Interferes with the formation of blood clots in the case of:

  • acute myocardial infarction;
  • vascular pathology of cerebral circulation;
  • unstable angina.

Interferes with formation of blood clots in case of unstable stenocardia.

Prescribed to patients who have the risk of embolism of the pulmonary artery, acute coronary thrombosis. Use of the drug is justified in the case of:

  • hypertension;
  • diabetes;
  • atherosclerosis, hyperlipidemia;
  • obesity;
  • prolonged immobilization;
  • conditions after vascular surgery.

The use of drugs is justified in the case of obesity.

It is prescribed to prevent the development of recurrent heart attacks, transient ischemic attacks, thrombosis of great vessels.

Contraindications

Due to the nature of the pharmacological action of the drug, its use is limited to the presence of:

  • ulcerative formations of the digestive system;
  • bleeding;
  • the triad of Ferian-Vidal;
  • allergic manifestations to drugs of the salicylate group;
  • bronchial asthma provoked by the use of nonsteroidal drugs;
  • pregnancy;
  • therapy with methotrexate.
The drug is contraindicated during pregnancy.
The drug is not prescribed in the event of manifestations of allergic reactions.
The use of the drug is limited to bronchial asthma.

Can not be used to treat children and adolescents.

Carefully

Increased attention in the appointment of medicines require:

  • obstructive pulmonary disease;
  • nasal polyposis, hay fever;
  • stomach diseases with high acidity;
  • abnormal liver and kidney function;
  • blood diseases;
  • use of methotrexate;
  • combined treatment regimens;
  • gout, hyperuricemia.

Increased attention in the appointment of medicines require stomach diseases with high acidity.

Treatment requires attention if patients have associated diseases, and other medications need to be prescribed.

How to take Aspicorus

Tablets should be taken whole, washed down with plenty of water. Take at the same time, before meals. The dosage and duration of treatment should be prescribed by a doctor.

To prevent thrombosis, the drug is prescribed from 100 to 300 mg per day. In an acute attack of chest pain, the first pill should be chewed.

With diabetes

The combined use of Aspicore and hypoglycemic drugs causes an increase in the effect of the latter. There is a risk of hypoglycemia. Control of blood glucose, kidney function is necessary, dieting is required,

Side Effects of Aspicore

Adverse reactions that occur when using the drug, often manifested by:

  • skin;
  • digestive tract;
  • central nervous system;
  • hematopoietic organs.

Adverse reactions that occur when using the drug, often manifested by the blood-forming organs.

The development of side effects due to the influence of the active substance on the receptors of the brain centers, the creation of high concentrations of salicylates in the blood plasma.

Gastrointestinal tract

Like all salicylates, it has the ability to cause dyspeptic symptoms. Dietary supplements, which include oxygenase inhibitors, are not recommended for combined use. This combination increases the risk of ulcerogenic effects. Side effects of the drug include the development of gastrointestinal bleeding.

Hematopoiesis

Thrombocytopenia may occur. With a deficiency of phosphate dehydrogenase causes hemolytic anemia.

Thrombocytopenia may occur. With a deficiency of phosphate dehydrogenase causes hemolytic anemia.

central nervous system

The accumulation of the active substance in the brain tissue is characterized by characteristic tinnitus, dizziness. Metabolites Aspikora cause temporary ringing in the ears in the appointment of large doses.

On the part of the respiratory system

Side effects of the respiratory system are manifested by the development of bronchospasm, expiratory dyspnea. Such reactions make it difficult to use drugs for the purpose.

Side effects of the respiratory system are manifested by the development of bronchospasm, expiratory dyspnea.

Allergies

Admission may cause skin rash, angioedema. Reactions of the immediate type are rare, require intensive care. Anaphylactic reactions in history - a reason to cancel the medication.

Influence on ability to operate mechanisms

In the presence of adverse reactions from the nervous system, it is necessary to refuse the works requiring increased attention.

In the presence of adverse reactions from the nervous system, it is necessary to refuse the works requiring increased attention.

special instructions

It is permissible to use the drug alone in pain and hyperthermia syndrome for no more than 3 days.

The ability to cause bleeding limits the use of the drug as an anti-inflammatory agent. Antiplatelet therapy should be carried out with constant monitoring of blood parameters. Examine fecal occult blood in case of prolonged use is necessary.

In order to ensure minimal blood loss during surgical interventions, including gynecology, taking the drug should be stopped a week before the operation.

The use of special drug release forms helps reduce the irritant effect of salicylic acid.

Use in old age

The pharmacokinetics of the drug changes with age:

  • hepatic metabolism decreases;
  • tissue distribution changes;
  • increases the time of elimination.

The reduction of plasma albumin, a decrease in renal clearance, an increase in the proportion of adipose tissue create conditions for increasing the concentration of the active substance and the development of side effects.

The use of drugs with the same toxicity in the elderly is unacceptable.

The presence of concomitant diseases with long-term medication needs regular monitoring of serum creatinine, blood pressure. Overdose leads to fatal consequences. The use of drugs with the same toxicity in the elderly is unacceptable.

Appointment to children

Not applicable in childhood and adolescence. Has a high risk of hemorrhagic complications. The use of Aspicore causes the development of bleeding, the occurrence of asthmatic attacks. Do not give medicine without prescribing a doctor.

Use during pregnancy and lactation

Not appointed in early pregnancy. There is a direct threat of congenital malformations in the fetus. The risk of prescribing a second trimester medication should be justified.
Penetration of the active substance through the placenta causes the development of hemorrhagic syndrome. Prenatal medication is dangerous in life-threatening situations.

Prenatal medication is dangerous in life-threatening situations.

A single dose of a small dose of the substance is not a contraindication for breastfeeding. Prolonged treatment in this period is associated with the abolition of breastfeeding.

Use in violation of kidney function

The purpose of the drug in patients with altered renal function, renal failure is undesirable. Reducing uric acid excretion provokes attacks of gout, even when using minimal doses.

Use in violation of the liver

Violation of hepatic metabolism reduces clearance by 30%, which requires individual dose titration. Prescribe medication for functional disorders of the liver should be carefully.

Prescribe medication for functional disorders of the liver should be carefully.

Overdose Aspicore

The severity of symptoms of poisoning depends on the dose of the drug. Clinical manifestations of moderate severity are characterized by:

  • nausea, vomiting;
  • dizziness;
  • visual impairment;
  • hearing loss, ringing in the ears;
  • violation of consciousness.

Dizziness may be a sign of drug poisoning.

The appearance of symptoms of poisoning requires an immediate reduction in the dose of the drug, strict medical supervision.

Severe salicylate poisoning requires immediate hospitalization, emergency care.

Signs of severe poisoning are characterized by:

  • ketoacidosis;
  • feverish state;
  • hyperventilation;
  • respiratory alkalosis;
  • loss of consciousness;
  • a sharp decrease in blood glucose levels;
  • heart failure, respiratory systems.

Signs of severe poisoning are characterized by loss of consciousness.

Patients need alkaline infusion, hemodialysis, electrolyte balance and blood rheology. Symptomatic therapy is prescribed as needed.

High salicylic acid concentrations indicate severe poisoning and poor prognosis.

Interaction with other drugs

The combined use of salicylic acid with medicines of different groups should have a rationale. The interaction is manifested by the development of the following reactions:

  • strengthening or weakening the target action;
  • the development of dangerous complications, toxic effects.

Without consulting a doctor it is not recommended to use the drug with other means.

Without consulting a doctor it is not recommended to use the drug with other means.

Contraindications

Prohibited sharing with antibiotics. Drugs block the action of each other, inhibit immunity.

Adverse reactions cause combination with diclofenac, ibuprofen, digoxin due to high plasma concentrations.

Adverse reactions cause combinations with diclofenac.
Do not take the drug at the same time as ibuprofen due to high plasma concentrations.
In combination with alcoholic beverages, it causes an additive effect.

Do not use in combination with methotrexate. Long-term therapy threatens the development of toxic effects, inhibits the hematopoietic system.

In combination with alcoholic beverages, it causes an additive effect. Direct threat of bleeding, multiple organ complications.

Combinations not recommended

Avoid joint use with heparin, other anticoagulants, thrombolytics to prevent gastric bleeding. Use with valproic acid requires caution. Manifestation of the negative impact on the gastrointestinal tract and the hematopoietic system.

Combinations that require caution

Corticosteroids, when taken together, reduce the level of salicylates in the body. Canceling hormones will cause overdose symptoms.

Do not exceed the dose to patients taking insulin, oral hypoglycemic agents. The risk of hypoglycemia requires constant medical supervision.

Antacids, which include aluminum and magnesium, reduce the effectiveness of salicylates.

Compatibility with alcohol

The additive effect of alcoholic drinks and salicylates has a negative effect on the body, regardless of the age and severity of the disease.

The additive effect of alcoholic drinks and salicylates has a negative effect on the body, regardless of the age and severity of the disease.

It creates a dangerous combination, manifested by severe adverse reactions. Excessive bleeding develops, liver function is disturbed, and severe reactions from the nervous system occur. This makes it impossible to jointly take the drug and alcohol.

Analogs

Contain the same active ingredient. Often used:

  • Taspir;
  • CardiASK;
  • ThromboASS;
  • Acecardol;

Thrombone ACC is an analogue of the aspikora.

Among foreign analogues often use Trombogard 100, Trombopol, Upsarin UPSA. The choice of the drug should make a doctor.

Pharmacy vacation terms

Can I buy without a prescription

Available in free sale.

Aspicore Price

Packs of 30 tablets are available from 63 rubles. For a package containing 90 tablets, the price is from 105 rubles.

Cardiac kardiask
ACECARDOL ® JSC "Synthesis"

Drug storage conditions

Store in places protected from light and moisture. Storage temperature not higher than + 25ĚŠ C. Keep out of the reach of children.

Shelf life

Shelf life - up to 2 years. Indicated on the packaging. Do not use after the specified date.

Manufacturer

Vertex JSC, Russia.

Aspicore Reviews

Inna, 56 years old, Belgorod

There were problems with the heart, increased blood pressure. She took medicine on the advice of a cardiologist for 2 weeks. The drug is freely available, the price is adequate. I feel much better.

Natalya, 27 years old, Kharkov

My husband has diabetes. The doctor prescribed a pill in a protective shell. For prevention, the dosage is convenient, taking 200 mg per day. No adverse reactions. Satisfactory condition.

Alina, 40 years old, Russia

The drug helps with problem skin. In order to hygiene the skin of the face, I make masks, in which it is included. Allows you to keep your skin in good condition.

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