Treatment and Prevention

Tio-Lipon-Novofarm preparation: instructions for use

Tio-Lipon Novofarm refers to the means that normalize metabolic processes. The drug affects the metabolism, restores lipid and carbohydrate metabolism. Helps reduce the concentration of cholesterol in the blood.

International non-proprietary name

INN: Thioctic acid (Thioctic acid).

Tio-Lipon Novofarm refers to the means that normalize metabolic processes.


ATX code: A16AX01

Forms of release and composition

Available in the form of a concentrate intended for dilution of the solution for subsequent intravenous administration. The concentrate is transparent, has a greenish-yellow shade. The main active ingredient is thioctic or lipoic acid. Additional components: propylene glycol, ethylenediamine and water for injection. The concentrate is produced in bottles. 10 pieces in a pack or 2 cell packs in a carton pack of 5 pieces each.

In tablets is not made.

pharmachologic effect

Thioctic acid is an antioxidant of endogenous origin. It promotes the binding of free radicals. This substance is formed in the process of decarboxylation of alpha-keto acids.

The drug has hypolipidemic, hypoglycemic, hypocholesterolemic and hepatoprotective effects.

The active substance is a coenzyme of multienzyme complexes of mitochondria, is directly involved in the oxidative processes of pyruvic acid. It helps to increase the concentration of glycogen, which is synthesized in the liver. The level of glucose in the blood decreases. This leads to overcoming insulin resistance.

Lipoic acid in its action is similar to the vitamins of group B. It participates in carbohydrate and lipid metabolism, stimulates the correct exchange of cholesterol, improves the nutrition of neurons and contributes to the normalization of liver function.

The drug has hypolipidemic, hypoglycemic, hypocholesterolemic and hepatoprotective effects.


With intravenous administration, the maximum concentration of active substances in the blood is observed after 10 minutes. Bioavailability and the ability to bind to the protein structures of the blood is quite low. The drug is excreted by the kidneys in the form of the main metabolites. The half-life is about an hour.

Indications for use

Direct indications for the use of the drug are:

  • prevention or treatment of diabetic polyneuropathy;
  • alcoholic neuropathy therapy;
  • various liver diseases.

Used in the treatment of conditions of acute intoxication of the body, such as mushroom poisoning, low-quality alcohol, heavy metal salts, chemicals.


Absolute contraindications that describes the instructions are:

  • lactose intolerance;
  • glucose-galactose malabsorption;
  • pregnancy;
  • lactation;
  • age up to 18 years;
  • hypersensitivity to the drug.


With caution and under strict medical supervision, the drug is prescribed for:

  • diabetes;
  • chronic alcoholism.

The drug is taken with great care in case of violations of the kidneys and liver, because The active substance has the ability to accumulate in the liver. When any deterioration in the results of tests, treatment is immediately stopped. Care must be taken and elderly people, because they are especially at risk for developing cardiovascular complications.

The drug is taken with great caution in case of violations of the kidneys and liver.

How to take Tio-Lipon Novofarm?

The solution is injected intravenously. Before the introduction of the concentrate must be diluted in an isotonic solution of sodium chloride. It is necessary to enter medicine slowly. Infusion therapy should last at least half an hour. The solution is used immediately after preparation, it should be protected as much as possible from the sun.

With alcoholic neuropathy, the drug is administered intravenously for 2 weeks. In the future, switch to drugs in pill form with a similar therapeutic effect.

For prophylactic purposes, 10 ml of solution diluted in 250 ml of sodium chloride over 10 days is administered. If necessary, the dosage can be increased.

With diabetes

Intravenous drip infusions are administered in 250 ml or 300-600 mg once a day. Such therapy is carried out within a month. After the end of the injection, the patient is transferred to the oral form of drugs. This treatment can be used for both men and women.

Side effects of Tio-Lipona Novofarm

The most frequent adverse reaction is hypoglycemia. Allergic reactions in the form of urticaria can also often occur. Long-term medication may cause nausea and heartburn. If a long time to enter the solution, there may be cramps, point hemorrhages under the skin and mucous membranes. Increased intracranial pressure and difficulty breathing can be observed with the introduction of a solution that is too fast.

Hypoglycemia is considered to be the most frequent adverse reaction.
Often from taking the drug Tio-Lipon-Novofarm may experience allergic reactions in the form of urticaria.
Long-term medication may cause nausea.
Heartburn is a side effect of the drug Tio-Lipon-Novofarm.
If the solution is injected for a long time, convulsions may occur.

Influence on ability to operate mechanisms

Because there is a risk of hypoglycemia, patients should be informed about this before you get behind the wheel. Special care must be taken when dealing with complex mechanisms.

special instructions

Patients who have a history of diabetes mellitus, you need to constantly monitor the level of glucose in the blood. To avoid the onset of symptoms of hypoglycemia, you need to reduce the dose of insulin used. Ampoules with solution are taken out of the package right before the injection. Bottles with a solution must be protected from sunlight.

Use in old age

Dosage adjustment required due to risk of hypoglycemia. In case of deterioration of the general condition of the dose is reduced to the minimum effective.

Appointment to children

This drug is not used in pediatric practice.

Use during pregnancy and lactation

Because the active substance penetrates through the protective barrier of the placenta, it can have a teratogenic and mutagenic effect on the fetus. Therefore, the use of medication in the period of gestation is prohibited.

Lipoic acid penetrates into breast milk. Therefore, at the time of treatment is better to refuse breastfeeding.

Use in violation of kidney function

Purpose of the drug depends on the clearance of creatinine. The higher it is, the smaller dose of medication prescribed.

Use in violation of the liver

Taking the drug in severe liver failure is not recommended.

Taking the drug in severe liver failure is not recommended.

Overdose Tio-Lipona Novofarm

The drug is well tolerated by patients, and signs of overdose almost never occur. If you accidentally take a large dose of medication, symptoms such as nausea, vomiting and severe headache, and hypoxia of the brain may appear.

The treatment in this case is symptomatic. If the symptoms of intoxication are too strong, carry out additional detoxification therapy.

Interaction with other drugs

It contributes to the weakening effect after taking Cisplatin. It is advisable to take it after lunch or in the evening. The activity is also reduced in the case of simultaneous administration with calcium and iron preparations, dairy products.

Ethanol greatly reduces the therapeutic effect of taking the medication. Insulin and other hypoglycemic drugs contribute to enhancing the therapeutic effect of taking thioctic acid.

Compatibility with alcohol

Instructions to the drug says that it can not be combined with alcohol intake. This leads to worsening symptoms of intoxication and weakening the effects of thioctic acid.


There are analogues that are available in the form of tablets in 30 mg film-coated tablets and solutions:

  • Berlition 300;
  • Berlition 600;
  • Lipoic acid;
  • Thiogamma;
  • Polition;
  • Thioctic acid;
  • Tiolepta;
  • Thioctic Acid-Vial;
  • Neurolipon;
  • Octolipene;
  • Lipotikson;
  • Espa-Lipon.

Pharmacy vacation terms

On prescription.

Can I buy without a prescription?


Price for Tio-Lipon Novofarm

Cost from 400 rubles for a concentrate for solution in 10 bottles.

Drug storage conditions

Storage space is selected dark and dry, temperature indicator + 25 ° C. Because thioctic acid is highly sensitive to light, and bottles should be kept in a carton until they are used directly.

Shelf life

Not more than 2 years.


LLC Novofarm-Biosintez, Novograd-Volynsky, Ukraine.

Reviews of Tio-Lipona Novofarm

Marina, 34 years old

Infusions of Tio-Lyon Novofarm were prescribed for diabetic polyneuropathy. You need to take medicine only on prescription. The course of treatment was 3 months. At the beginning of the course of therapy, the medicine was prescribed to be administered into a vein, and then, to maintain, they were transferred to similar tablets. Analyzes improved. The metabolism in my body returned to normal. The drug is excellent with a minimum of side effects.

Pavel, 28 years old

The only disadvantage of this drug - it is rarely possible to immediately buy it at the pharmacy. You only need to pre-order. The drug has good antioxidant properties. It became easier after the course of treatment, the general condition improved significantly. The price is good, there are practically no side effects. At the beginning of the treatment, my head was spinning a little, but then everything went away. I advise the drug.

Pavlova MP

I am a neurologist. I prescribe this drug often, because It has an effective antioxidant effect in polyneuropathy. In practice, I use this medication for the treatment of the liver, complex therapy of neuritis and radiculopathy. The drug has a minimum of side effects and an affordable price.

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