Treatment and Prevention

The action of the drug Byetta Long with diabetes

Long Bayet belongs to the group of hypoglycemic agents for parenteral administration. Injections put under the skin. The mechanism of action is based on the pharmacological properties of exenatide, which affects the receptors of glucagon-like peptide-1. The active ingredient allows you to improve insulin production before glucose comes from food. At the same time, the hormonal activity of the beta cells of the pancreas decreases when the normal blood sugar levels are reached.

International non-proprietary name


Long Bayet belongs to the group of hypoglycemic agents for parenteral administration.



Forms of release and composition

The drug is made in the form of white powder for the manufacture of subcutaneous injections. The drug has a prolonged action. Powder sold with solvent. The latter is visually a clear liquid with a yellow or brown tint. The powder contains 2 mg of the active substance, exenatide, which is supplemented with sucrose and a polymer as auxiliary components.

Solvent contains:

  • croscarmellose sodium;
  • sodium chloride;
  • sodium dihydrophosphate in the form of monohydrate;
  • sterile water for injection.

pharmachologic effect

The drug belongs to the group of incretin mimetics - GLP-1. When activated, glucagon-like peptide-1 exenatide enhances hormone secretion of insulin by beta cells of the pancreas before the intended food intake. The drug slows gastric emptying when it enters the bloodstream. Byta's active compound enhances the sensitivity of tissues to the action of insulin, thereby improving glycemic control against the background of insulin-independent diabetes. Insulin production stops when blood sugar levels fall to normal.

During clinical studies revealed that the introduction of exenatide reduces appetite and reduces the level of food intake.

Exenatide chemical structure differs from the molecular structure of insulin, derivatives of D-phenylalanine and sulfonylurea, alpha-glucosidase blockers and thiazolidinediones. The medicinal substance improves the function of the pancreatic islets of Langerhans. At the same time, exenatide inhibits glucagon secretion.

During clinical studies it was revealed that the administration of exenatide reduces appetite and reduces the level of food intake, inhibits gastric motility. The active substance enhances the hypoglycemic effect of other antidiabetic agents.


After subcutaneous administration, the drug accumulates in the bloodstream, without being subjected to biotransformation in the liver cells. The average distribution of exenatide is about 28 liters. The active substance leaves the body through glomerular filtration through the kidneys, followed by proteolytic cleavage. Fully medication is removed only 10 weeks after the end of therapy.

Hypoglycemic agent is necessary to reduce the serum sugar concentration in the blood in type 2 diabetes.

Indications for use Baeta Long

Hypoglycemic agent is necessary to reduce the serum sugar concentration in the blood in type 2 diabetes. It is strictly forbidden to inject medication for type 1 diabetes. The drug is used with low efficiency measures to reduce excess weight: increased physical exertion, special nutrition.


The drug is contraindicated in people with:

  • insulin-dependent diabetes;
  • individual hypersensitivity to the additional and active substances of the drug;
  • severe renal failure;
  • severe perforation ulcerative erosive lesions of the digestive tract;
  • diabetic ketoacidosis;
  • children under 18;
  • pregnant and lactating women.
The drug is contraindicated in people with severe renal failure.
The drug is contraindicated in people with ulcerative erosive lesions of the digestive tract.
The drug is contraindicated in children under 18 years.

How to take Baetu Long

The drug is injected subcutaneously in the thighs, the anterior abdominal wall and under the skin above the deltoid muscle or in the forearm.

The dosage at the initial stage of therapy reaches 5 mg, the frequency of administration per day - 2 times. The drug must be used within 60 minutes before the start of the meal on an empty stomach. It is recommended to put injections before breakfast and before dinner. One month after the start of drug therapy, with good tolerability, an increase in dosage up to 10 mg is allowed for administration twice a day.

Side Effects of Baet Long

Side effects from the use of the drug can be caused by improper use of the drug or negative interaction with another drug. The occurrence of adverse reactions must be reported to your doctor.

Gastrointestinal tract

When using Baeta as a monotherapy, the development is possible:

  • nausea;
  • vomiting;
  • constipation;
  • prolonged diarrhea;
  • loss of appetite, anorexia;
  • dyspepsia.
When using Baeta as a monotherapy, nausea may develop.
When using Baeta as a monotherapy may develop constipation.
When using Baeta as a monotherapy, anorexia may develop.

In combination therapy, the described adverse reactions are complemented by an increased risk of ulceration of the stomach and duodenum, inflammation of the pancreas, disorder of taste buds, pain and abdominal distention, flatulence, belching.


With the oppression of the hematopoietic system, the concentration of blood corpuscles decreases.

central nervous system

Disturbances of the nervous system manifest as dizziness, headache, weakness, and drowsiness. In rare cases, there is a quiver of brushes.

On the part of the urinary system

With the simultaneous use of other drugs may develop renal failure or exacerbation. Possible increase in serum creatinine concentration.

On the part of the endocrine system

With the abuse of medication may develop hypoglycemia. Especially with parallel use of sulfonylurea derivatives.

With the abuse of medication may develop hypoglycemia.


Allergic reactions are characterized by the development of skin rashes, itching, angioedema, urticaria, hair loss, anaphylactic shock.

Influence on ability to operate mechanisms

Hypoglycemic drug does not affect cognitive function, fine motor skills and the nervous system. Therefore, during the period of treatment, it is allowed to work with complex mechanisms, driving and other activities requiring high speed of physical and mental reactions, concentration.

special instructions

It is not recommended to enter exenatide after eating food. It is forbidden to put intravenous and intramuscular injections.

Medicinal substances have potential immunogenicity, due to which the patient's body in the presence of hypersensitivity can produce antibodies against active ingredients. In most cases, the antibody titer was minimal and did not lead to the development of anaphylactic reactions. Within 82 weeks of drug therapy, a gradual decrease in the immune response was observed, so the drug did not pose a threat to life due to the possible development of anaphylactic shock.

It is forbidden to put intravenous and intramuscular injections.

In rare cases, exenatide can slow down the motility of the smooth muscles of the gastrointestinal tract. Therefore, parallel use of drugs that inhibit intestinal peristalsis or require rapid absorption from the digestive tract is not recommended.

After the abolition of drug therapy, the hypotensive effect may persist for a long time, because the level of exenatide in plasma decreases within 10 weeks. If, after discontinuation of the drug, the doctor prescribes another drug therapy, it is necessary to warn the specialist about the previous introduction of Byet. This is necessary to avoid negative reactions.

In clinical practice, there have been cases of rapid weight loss (about 1.5 kg per week) during therapy with exenatide. Sharp weight loss can cause negative effects: fluctuations in hormonal levels, increased risk of cardiovascular pathologies, exhaustion, the development of depression, and kidney prolapse are possible. When weight loss is necessary to control the signs of cholelithiasis.

Use in old age

Persons over 60 years old are not required to additionally adjust the treatment regimen.

Persons over 60 years old are not required to additionally adjust the treatment regimen.

Appointment to children

The use of the drug in childhood is prohibited due to the lack of information on the effect of the drug on the development of the human body until the age of 18.

Use during pregnancy and lactation

During preclinical testing of the drug in animals, a toxic effect on the internal genital organs of the mother and a teratogenic effect on the fetus were detected. When the drug is used by pregnant women, intrauterine abnormalities may occur, disorders in the development of organs and tissues in the process of embryogenesis. Therefore, the use of Baeta women during pregnancy is prohibited.

During treatment with a hypoglycemic drug, it is recommended to cancel breastfeeding due to the likelihood of hypoglycemia in a child.

Use in violation of kidney function

When the drug was used by patients with severe renal failure, an increase in the incidence of adverse reactions from the gastrointestinal tract was observed. Especially with creatinine clearance below 30 ml / min. In this regard, the subcutaneous administration of Byeta to persons with renal dysfunction is prohibited.

The drug is contraindicated for use in persons with severe liver disease.

Use in violation of the liver

The drug is contraindicated for use in persons with severe liver disease.


In the post-marketing practice there were cases of overdose, the clinical picture of which was the development of gag reflexes and nausea. In this case, the patient is prescribed treatment to eliminate the symptoms. To reduce the likelihood of overdose, you can not abuse the drug. In the absence of hypoglycemic action, it is necessary to switch to replacement therapy, an independent increase in the dosage or frequency of administration of Byetta is contraindicated. The maximum frequency of use - 2 times a day.

Interaction with other drugs

Exenatide with a parallel appointment with Digoxin reduces the volume of the maximum serum concentration of the latter by 17%, the time to reach it is increased by 2.5 hours. However, such a combination therapy does not affect the general well-being of the patient and is allowed to use.

With the simultaneous administration of Baet Long with Lovastatin, a decrease in the maximal plasma levels of Lovastatin by 28% is observed, the time for reaching Cmax increases by 4 hours. With this change in pharmacokinetic parameters, correction of the dosage regimen of both drugs is necessary.

Exenatide with a parallel appointment with Digoxin reduces the volume of the maximum serum concentration of the latter by 17%, the time to reach it is increased by 2.5 hours.

Acceptance of HMG-CoA reductase inhibitors does not affect fat metabolism. There was no change in the concentration of Exenatide in combination with Metformin, Thiazolidinedione.

In patients taking 5–20 mg of the daily dose of Lisinopril to normalize high blood pressure, while using Exanthide, the time to reach the maximum level of lisinopril in plasma was increased. Changes in pharmacological parameters

When combined with warfarin, postmarketing studies have documented cases of internal bleeding and an increase in the period of reaching the maximum concentration of warfarin by 2 hours. This combination is not recommended for use as a combination therapy. With the necessary application at the initial stage of treatment, the patient needs to control the level of coumarin and warfarin derivatives in the blood plasma.

Compatibility with alcohol

Hypoglycemic drug is not allowed to use with alcohol withdrawal syndrome. During treatment, it is strictly forbidden to drink alcohol. Ethyl alcohol can increase the likelihood of hypoglycemia and other negative reactions. Ethanol has a negative effect on liver cells, increasing the risk of fatty degeneration.


Byetu Long with low or no therapeutic effect is allowed to replace one of the following drugs that have a similar hypoglycemic effect:

  • Byet;
  • Exenatide;
  • Viktoza;
  • Forsig;
  • NewNorm
Baet instructions
Viktoza instruction

Pharmacy vacation terms

Free sale of the drug without the advice of a doctor is prohibited.

Can I buy without a prescription

Due to the possible development of hypoglycemia when taking without direct medical indications it is impossible to acquire the medicine without a medical prescription.


The average cost of the drug on the pharmaceutical market varies from 5 322 to 11 000 rubles.

Drug storage conditions

It is recommended to contain medicinal powder in a place isolated from exposure to sunlight, at a temperature of + 2 ... + 8 ° С. After opening the package, storage at a temperature of up to + 30 ° С for up to 4 weeks is allowed.

Shelf life

3 years.


Amylin Ohio ElSi, USA.

When combined with warfarin, postmarketing studies have documented cases of internal bleeding.


Miroslav Belousov, 36 years old, Rostov-on-Don

I have non-insulin dependent diabetes. I accept Baetu together with insulin injections for about a year. The drug effectively copes with its task - sugar stabilized from 13 mmol to 6-7 mmol. There were interruptions in the delivery of insulin to the city, I had to put only subcutaneous injections byeta. Sugar remained normal. I have a liver disease in parallel, so I consulted with my doctor before using the drug. Byetta did not aggravate the disease, so I leave positive feedback.

Evstafiy Trofimov, 44 years old, St. Petersburg

At the next medical examination revealed elevated blood sugar. Indicators rose due to severe stress. Diagnosed with type 2 diabetes. Appointed injections Baet Long. Putting under the skin is more convenient with the help of a syringe pen. I introduce the drug for about 6 months. The medicine alone does not work. With the passage of drug therapy required a special diet and exercise. Then the sugar is reduced to normal. I noticed that in the course of treatment I lost 11 kg of excess weight, my blood pressure decreased. It is important to put injections strictly according to the instructions.

Natalya Solovyova, 34 years old, Krasnoyarsk

I have type 2 diabetes. I put injections with exenatide for about a year. Weight has not decreased. After an evening injection, the appetite rises and I want to eat non-stop. This is such a side effect. If you control yourself, the sugar remains normal.I recommend people with a similar problem when they increase their appetite to go for walks in order to eliminate the temptation. In the morning, sugar is kept in the range of 6-7.2 mmol. The only downside is the high price.

Watch the video: Type 2 Diabetes Drugs Januvia, Janumet, Byetta & Victoza: Lawsuits, Settlements & Claims (February 2020).