Glucophage 1000 mg: reviews for diabetes and the price of tablets

For the treatment of diabetes requires effective and safe medicines, one of which is Glucophage 1000.

The drug belongs to the biguanides - hypoglycemic drugs used in the treatment of diabetes of different types. Metformin is an active component of all hypoglycemic drugs (Metformin, Glyukofazh, Siofor, etc.).

In addition to the proven effectiveness and relatively low price, Glucophage is now considered one of the most frequently prescribed drugs.

Properties of the drug

Diabetes mellitus is an endocrine disorder formed under the influence of various factors. The main manifestations of the disease are elevated blood sugar levels, with some types of disease, insulin immunity of cells (insulin resistance) and an increase in body weight due to increased appetite. The drug Glucophage 1000 mg helps patients cope with these manifestations of the disease.

The most pronounced effect of the drug - hypoglycemic. But, unlike some other drugs, this effect is not achieved as a result of stimulating insulin production in the pancreas. For this reason, taking Glyukofazh does not cause a low concentration of glucose in the blood (hypoglycemia), and therefore will not cause a hypoglycemic coma. In addition, even in healthy people taking the drug to control the level of sugar or weight loss, hypoglycemia does not develop.

The sugar lowering effect is achieved due to the effect on peripheral receptors - they become more sensitive to insulin. In addition, cell utilization increases glucose.

In addition, the drug has other properties. It slows down the absorption of glucose in the intestine and inhibits the formation of glucose in the liver. In addition to the hypoglycemic effect, Glucophage improves fat metabolism.

The main component of the drug, metformin, stimulates the process of glycogen production.

Additionally, the drug helps patients with obesity and overweight to reduce the amount of fat in the subcutaneous tissue, which facilitates the patient's condition, improves health. Taking the drug can reduce appetite, which also helps in weight loss. For these reasons, in some cases, Glucophage tablets are also used by healthy people to lose weight.

However, few people notice a decrease in appetite, as well as the drug does not always allow to achieve the goal.

Features and forms of release of the drug

The composition of the drug contains the active substance - metformin and additional components.

The peculiarity of the drug is that when consumed a significant part of the main component is absorbed. Eating is allowed to slow down this process; therefore, Glucophage should be taken only with food or immediately after a meal.

Bioavailability of the drug - 50-60%. The active ingredient quickly enters the tissue. Plasma protein binding occurs, but to a small extent. The highest content of the drug in plasma is achieved in 2.5 hours.

Metformin is extremely low in metabolism. From the body excreted fairly quickly: half of the drug is excreted through the kidneys after 6.5 hours.

The drug Glucophage is intended only for oral administration.

Tablets vary in concentration of the active ingredient:

  • 500 mg;
  • 850 mg;
  • 1000 mg.

At the same time tablets with a lower concentration of metformin (500 and 850 g) are round, biconvex. Tablets 1000 mg - oval, on one side there is an engraving "1000".

Glucophage is sold in packs, each containing 3 cells. Each cell contains 20 tablets.

Indications and contraindications for use of the drug

Due to the effective reduction of glucose, Glucophage is prescribed primarily for diabetes of insulin-independent type. Diabetics suffering from obesity, which diet therapy and training did not help to get rid of excess weight and high sugar, are most in need of quality treatment.

Glucophage is also prescribed to patients with prediabetes, if there are risk factors for diabetes to become explicit.

The instructions indicate that the drug can be treated adults and children over 10 years. In this case, the use of Glucophage as the main drug, and simultaneously with a number of drugs, including insulin, is permitted. Admission Glyukofazh in combination with insulin is justified in diabetics with obesity.

The drug has contraindications:

  1. Diabetic coma, precoma, ketoacidosis.
  2. The presence of manifestations of the disease in acute or chronic form, because in this case there is a high risk of tissue hypoxia.
  3. Diseases of the kidneys and liver.
  4. Recently suffered serious injuries or surgeries whose therapy involves the use of insulin.
  5. Lactic acidosis, including in the anamnesis.
  6. Individual intolerance to metformin or other components of the drug.
  7. Low-calorie diet (with a daily caloric intake of less than 1000 kcal).
  8. Infectious diseases.
  9. Hypoxia.
  10. Alcoholism or alcohol poisoning.
  11. X-ray using a contrast agent based on iodine.

A relative contraindication is considered to be the age of a person - patients over the age of 60 take Glucophage is not recommended, since in this case the likelihood of developing lactic acidosis is high. It is permissible to use the drug only with constant monitoring of the state, especially the correct functioning of the kidneys.

Receiving Glyukofazh is contraindicated during pregnancy and lactation. If pregnancy is planned or occurs during the course of treatment, the use of the pill should be stopped. In addition, the analogs are also not suitable - the medication is replaced by insulin injections. There is no reliable information about the ability of Glyukofaz components to get into the milk, during breastfeeding it is also better to refuse the drug. If there is an urgent need to continue treatment with Glucophage, breastfeeding will have to stop.

Additional recommendations when using the drug

The decision on the use of Glucophage in the process of treatment is made by the attending physician.

Before making a decision on the use of a drug, the attending physician prescribes an examination of the body. The purpose of this survey is to establish the true state of the body.

The correct selection of the dosage and precise compliance with the instructions for use when taking Glyukofazh 1000, side effects appear to a lesser extent, but the likelihood of their occurrence remains.

Among the side effects are most characteristic:

  • Allergy - pruritus, rash;
  • problems with the digestive tract.
  • taste of metal in the mouth,
  • diarrhea,
  • vomiting
  • nausea,
  • abdominal pain,
  • flatulence,
  • loss of appetite.

Disorders of the digestive tract are usually observed at the very beginning of the reception Glucophage. Usually after some time they pass without additional treatment. Reducing the severity of these symptoms can be achieved by taking antispasmodics or anthocin, as well as the strict observance of the rules of admission (only after or during a meal).

Violation of metabolic processes - lactic acidosis - a dangerous condition that can be fatal. The development of lactic acidosis is accompanied by characteristic symptoms (drowsiness, difficulty breathing, a change in heart rate, abdominal pain), and a lack of vitamin B12.

With lactic acidosis, the patient needs urgent hospitalization and skilled care. Other side effects are usually temporary, and with long-term use of the drug pass quickly enough. However, if the negative manifestations are very disturbing, it makes sense to stop taking Glucophage and consult with your doctor. He will help to adjust the regimen or advise the drug analogues.

When you use 85 g or more of the drug comes overdose. Even with this amount Glucophage does not cause a sharp decrease in blood sugar levels, but provokes the development of lactic acidosis. The condition is manifested by such symptoms as increased body temperature, pain in the abdomen and muscles, dizziness, impaired consciousness, rapid breathing, nausea, diarrhea, vomiting, coma. If you suspect milk acidosis, the patient should be hospitalized as soon as possible. The concentration of lactate is determined in the hospital, a diagnosis is made.

In order to remove lactate from the body, symptomatic treatment and hemodialysis procedure are prescribed.

Instructions for use of the drug

Before using the drug, it is necessary to study the description and detailed instructions for use. Compliance with the recommendations helps to avoid the occurrence of side effects and undergo treatment as comfortably as possible.

For each patient, how much to take the drug is determined individually. The dosage depends on the level of glucose in the blood. The minimum amount of the drug is 500 mg, that is, 1 tablet Glucophage 500 or ½ Glucophage 1000. You need to take Glucophage 2-3 times a day. To avoid absorption of the active substance, tablets should be taken either with food or immediately after a meal, but not on an empty stomach. 1-2 weeks after the start of administration, the dosage is increased based on the results of glucose measurement and in the absence of side effects. A gradual increase in dosage reduces the risk of side effects from the gastrointestinal tract. The maximum therapeutic dosage is 3 g per day, divided into 3 doses. Maintenance dosage should be lower - no more than 1.5-2 g per day.

With a low efficacy of a hypoglycemic drug, the patient can be transferred to receive Glucophage. In this case, the first drug should be canceled and start taking Glucophage with the minimum allowable amount.

In difficult cases of type 2 diabetes, patients need a comprehensive treatment that combines the use of anti-hypoglycemic drugs and insulin administration. Reviews left by patients suggest that Glucophage is often recommended for reducing sugar in such cases. The usual initial dosage is 500-850 mg 2-3 times a day. The amount of insulin is selected for each patient separately, depending on the level of glucose.

In patients older than 60 years, the maximum dosage is 1000 mg per day. During treatment, it is necessary to undergo regular examinations to regulate the functioning of the kidneys.

For the treatment of type 2 diabetes in children, the drug is used both as the main drug and in combination with insulin. Treatment should begin with a minimum dosage of 500 mg, and then gradually increase it to a maximum of 2000 mg per day. The entire amount of the drug is divided into 3 doses.

Glucophage tablets should be taken only as a whole, without chewing. You can drink the required amount of water.

Cost and analogues of the drug

Glyukofazh drug can be purchased in ordinary urban pharmacies, but it does not apply to drugs in the free market. To get the drug, you must have a prescription with your doctor.

The retail price of the drug varies depending on the region of sale and the form of release of the drug. Glucophage 500 tablets will be cheaper, their cost is on average between 120 rubles (30 tablets per pack) and 170 rubles (60 tablets). The price for Glucophage 1000 varies between 190-200 rubles (30 tablets) and 300 rubles (60 tablets).

If Glyukofazh is not available in pharmacies of the city, or causes strong side effects, the attending physician may drink drugs analogues. These drugs include:

  1. Metformin
  2. Glyminfor,
  3. Siofor,
  4. Metfohamma,
  5. Formetin,
  6. Langerin,
  7. Nova Met et al.

Store the drug should be in a dark cool place - the ambient temperature should not exceed 25 degrees. The place must be inaccessible to children. Storage time is 3 years for Glucophage tablets 1000 and 5 years for Glucophage 500 and 850. After the expiration date, the drug is prohibited. Expiration date is indicated on the package.

On the hypoglycemic drug Glyukofazh described in the video in this article.

Watch the video: How To Take Metformin. How To Start Taking Metformin. How To Reduce Metformin Side Effects 2018 (February 2020).